Paul J Hagerman Selected Research

5' Untranslated Regions (5' UTR)

1/2019	Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions.
4/2014	Transcription-associated R-loop formation across the human FMR1 CGG-repeat region.
3/2013	Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.
1/2013	Sequencing the unsequenceable: expanded CGG-repeat alleles of the fragile X gene.
3/2011	Initiation of translation of the FMR1 mRNA Occurs predominantly through 5'-end-dependent ribosomal scanning.
8/2010	Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome.
3/2010	A novel FMR1 PCR method for the routine detection of low abundance expanded alleles and full mutations in fragile X syndrome.
11/2009	Translation of the FMR1 mRNA is not influenced by AGG interruptions.
9/2007	Secondary structure and dynamics of the r(CGG) repeat in the mRNA of the fragile X mental retardation 1 (FMR1) gene.
3/2004	Redistribution of transcription start sites within the FMR1 promoter region with expansion of the downstream CGG-repeat element.

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Paul J Hagerman Research Topics

Disease

44	Fragile X Tremor Ataxia Syndrome 01/2021 - 01/2004
21	Intellectual Disability (Idiocy) 01/2019 - 01/2003
18	Fragile X Syndrome (Martin Bell Syndrome) 01/2019 - 10/2003
12	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 07/2004
3	Tremor (Tremors) 03/2014 - 05/2003
2	Alzheimer Disease (Alzheimer's Disease) 11/2014 - 03/2014
2	Disease Progression 08/2011 - 06/2011
2	Autistic Disorder (Autism) 08/2011 - 11/2008
2	Parkinson Disease (Parkinson's Disease) 02/2009 - 07/2007
2	Ataxia (Dyssynergia) 10/2006 - 05/2003
2	Movement Disorders (Movement Disorder) 10/2006 - 01/2003
1	Neurodevelopmental Disorders 01/2022
1	Inflammation (Inflammations) 01/2020
1	Autism Spectrum Disorder 06/2014
1	Neurobehavioral Manifestations 03/2014
1	Protein Deficiency 01/2014
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2014
1	Hypersensitivity (Allergy) 05/2013
1	Friedreich Ataxia (Friedreich's Ataxia) 08/2011
1	Gait Ataxia 08/2011
1	Neuroblastoma 06/2011
1	Brain Diseases (Brain Disorder) 08/2010
1	Autoimmune Diseases (Autoimmune Disease) 08/2008
1	Myotonic Dystrophy (Dystrophia Myotonica) 04/2007
1	Central Nervous System Diseases (CNS Diseases) 01/2007
1	Cognitive Dysfunction 10/2006
1	Memory Disorders (Memory Loss) 10/2006
1	Parkinsonian Disorders (Parkinsonism) 10/2006
1	Laminopathies 12/2005
1	Mental Disorders (Mental Disorder) 11/2005
1	Learning Disabilities (Learning Disability) 01/2004

Drug/Important Bio-Agent (IBA)

29	Messenger RNA (mRNA)IBA 09/2014 - 01/2003
15	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
12	5' Untranslated Regions (5' UTR)IBA 01/2019 - 10/2003
12	RNA (Ribonucleic Acid)IBA 04/2014 - 07/2004
7	ElementsIBA 06/2014 - 12/2003
3	UbiquitinIBA 10/2016 - 05/2003
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 11/2014 - 05/2013
3	Fragile X Mental Retardation ProteinIBA 05/2013 - 01/2003
3	Lamin Type A (Lamin A)IBA 01/2010 - 12/2005
3	DNA (Deoxyribonucleic Acid)IBA 02/2009 - 07/2007
2	ProteomeIBA 01/2021 - 01/2020
2	Peptides (Polypeptides)IBA 01/2020 - 01/2019
2	Memantine (Namenda)FDA Link 11/2014 - 03/2014
2	MicroRNAs (MicroRNA)IBA 09/2014 - 03/2013
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2012 - 04/2010
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 08/2011 - 08/2010
1	phosphoserine aminotransferase (phosphoserine transaminase)IBA 01/2020
1	TenascinIBA 01/2020
1	enhanced green fluorescent proteinIBA 01/2019
1	CalciumIBA 01/2017
1	Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA 01/2016
1	Glutamic Acid (Glutamate)FDA Link 11/2014
1	Biological ProductsIBA 09/2014
1	Adenosine Triphosphatases (ATPase)IBA 08/2011
1	FrataxinIBA 08/2011
1	Aconitate Hydratase (Aconitase)IBA 08/2011
1	oligomycin sensitivity-conferring protein (complex V)IBA 08/2011
1	IronIBA 08/2011
1	ZincIBA 08/2011
1	Untranslated Regions (Untranslated Region)IBA 08/2011
1	Doxycycline (Periostat)FDA LinkGeneric 06/2011
1	NAD (NADH)IBA 08/2010
1	Oxygen (Dioxygen)IBA 08/2010
1	Adenosine Triphosphate (ATP)IBA 08/2010
1	NeurotoxinsIBA 08/2010
1	Flavin-Adenine Dinucleotide (FAD)IBA 08/2010
1	Crystallins (Crystallin)IBA 08/2008
1	Biomarkers (Surrogate Marker)IBA 06/2008
1	NestinIBA 01/2005
1	CytosineIBA 01/2004
1	GuanineIBA 01/2004

Therapy/Procedure

2	Therapeutics 09/2012 - 10/2006
1	Activities of Daily Living (ADL) 10/2009